HMEC is a cell line that was derived from the human mammary epithelial cells of a female patient who had been suffering from breast cancer. HMEC cells exhibit a cuboidal morphology and a characteristic pattern of swirls. They also exhibit adherent cultural properties, forming monolayers when grown in vitro. HMEC can be used as a transfection host to study breast cancer and oncogenesis, and an HMEC transfection reagent to transfect HMEC cells is commercially available from Altogen Biosystems. The HMEC cell line can also be used for carcinogen screening, developing therapeutics, and three dimensional culturing.
HMEC cells were derived from the glandular tissue of a human patient, and are one of the primary breast cancer in vitro models available to researchers. The HMEC cell line is capable of acetylated LDL uptake, and expresses several factors such as von Willebrand's factor. The cells are important for biomedical research into the morphological and physiological evolution of breast cancer. Growing in cuboidal colonies with characteristic swirls, HMEC cells can be efficiently transfected with liposomic reagents , giving information as to how breast cancer tissue is affected by foreign substances and internal mutations in cellular genomes.
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